Endocrine Abstracts

Introduction: Metformin-induced lactic acidosis (MALA) is one of the most important drug toxicities with high morbidity and mortality rates. Nonspecific symptoms such as nausea, vomiting, epigastric pain, hypotension, tachycardia, tachypnea, arrhythmia, renal insufficiency, coma and cardiac arrest can be seen. Here we are presenting a case with acidosis due to metformin overdose.Case: A 36-year-old female patient with a history of type 2 diabetes for thr...

Vitamin D role is not only associated with mineral metabolism and bone health but also in globally important diseases such as obesity and metabolic syndrome. The aims of this study were to investigate: i) 25(OH) vitamin D levels in obese patients with and without metabolic syndrome and compare these with levels in healthy subjects, ii) the relationship between serum 25(OH) vitamin D levels and metabolic syndrome components such as body mass index, waist circumference, blood pr...

Introduction: Acromegaly is a clinical syndrome associated with excess growth hormone. The present study aimed to investigate sarcopenia and frailty, which could affect mortality and morbidity, in patients with acromegaly.Method: Twenty outpatients diagnosed with acromegaly were included in the study. The hand muscle strength of the patients was measured by electronic hand dynamometer (Model EH101, Zhongshan Camry Electronic Co. Ltd. China). Computed tom...

Introduction and aim: Osteopetrosis is a rare genetic disorder of reduced osteoclastic bone resorption. Defective bone remodelling induces skeletal sclerosis and abnormally dense but brittle bones. We present here a case of autosomal dominant osteopetrosis type II as a cause of high bone mineral density (BMD).Case report: A 52-years-old woman with a complaint of bone pain and headache referred to our clinic for evaluation of high BMD. Her medical history...

Introduction: Thyrotropin secreting pituitary adenomas are rare constituting <2% of pituitary adenomas. Thirty percent of these tumors may be plurihormonal. Most common cosecreted hormone is GH and the least one is PRL. We report here a case of plurihormonal pituitary adenoma symptomatic for TSH secretion.Case report: A 35-year-old female admitted to hospital because of fatigue, heat intolerance, headache, galactorrhea and menstrual irregularity. Her...

Thyroidectomy is the definitive treatment for toxic multinodular goiter (TXMNG). Surgery should be performed when the patient is euthyroid which decreases perioperative cardiac risks. Plasmapheresis is a procedure that removes the thyroid hormones from the circulation. It is an alternative method in case of resistance or contraindications to anti thyroid drugs. Role of plasmapheresis in the treatment of TXMNG is not fully determined in the literature. We report a case with TXM...

Introduction: Sertoli–Leydig cell tumours are rare tumours which account for <1% of all solid ovarian tumors. It mostly occurs in 2–4° decades of life. Rapidly progessing symptoms/signs of androgen excess suggest the presence of and androgen secreting tumor.Case: Two postmenopausal patients (50 and 57 year-old) were referred to our Endocrinology Clinic for evaluation of worsening hirsutism. Both of patients had manifestations of hypera...

Purpose: The aim of this study in new diagnosed adult women with polycystic ovary syndrome (PCOS) was to evaluate carotid intima media thickness (CIMT) and visceral fat thickness (VFT) measurement by ultrasonography and which method can be used for atherosclerosis risk follow-up.Methods: A case-control study was conducted on 22 PCOS women (18–30 years of age) and 22 controls. BMI was matched volunteer controls. Two different criteria were used to as...

Introduction: Schwannomas are benign, encapsulated, solitary, slow-growing tumors which originate from nerve sheath cells in cranial, periferic, symphathetic nerve system. Aproximately, 25–45% of schwannomas are in head and neck region. N. Vagus Schwannoma are seen relatively, rarely. The patients frequently apply with a slow-growing, painless servical mass. Malign transformation is unusual.Case report: The patient 37 years old applied to our clinic...

Background/purpose: The combination of DM and HT accelerates vascular complications and increases the risk of mortality and morbidity. Hypertension is seen in half of diabetic patients. HT can be detected in approximately 40% of newly diagnosed diabetic patients. DM frequency increased 2.5 times in hypertensive patients. The association of HT and DM is due to the common mechanism responsible for the pathogenesis of both diseases. There is a limited number of studies investigat...